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Tony Adkins, a physician assistant at CHOC, is quickly becoming famous on social media with his dances to entertain sick kids. Photographed at Children’s Hospital of Orange County in Orange on Friday, Aug. 31, 2018. (Photo by Kevin Sullivan, Orange County Register/SCNG)
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Thompson AM, Blaser A, Anderson RF, Shinde SS, Franzblau SG, Ma Z, Denny WA, Palmer BD (2008) Synthesis, reduction potential and anti-tubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6- -6,7-dihydro-5 H -imidazo[2,1-b][1,3]oxazine. J Med Chem 52(3):637–645.
ARU-1801 is an investigational gene therapy for sickle cell disease and β-thalassemia. -1801 utilizes proprietary technology intended to increase functioning red blood cells by inserting a modified fetal hemoglobin gene into autologous stem cells through a lentiviral vector. Studies have indicated that sickle cell patients with elevated levels of fetal hemoglobin have fewer vaso-occlusive crises and hospitalizations, due in part to improved characteristics of fetal hemoglobin relative to adult hemoglobin. -1801 is the only known clinical-stage gene therapy to deliver the gene encoding fetal hemoglobin, which has been modified to optimize oxygen carrying capacity and anti-sickling properties.
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Reported $2 billion in revenue in 2016. As one of the few pharmaceutical companies based in South Africa, it has seen growth by focusing on emerging markets in Asia. It continues to look for companies to acquire to add to its portfolio of medications.
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For example, one may not know which exact cow produced a given gallon of milk, but one often knows the farm or the state from which the milk originates, especially if the product is expensive and from an organically reared cow. Similarly, consumers could demand greater knowledge of the drugs they buy, and some will undoubtedly want drugs made with fewer or no ingredients from India or China. It is likely that the best Indian companies, if they started to lose business and revenue, would establish their own independently verified quality-control systems and allow—even demand—that the FDA have unfettered access, which would ensure Western purchasers were satisfied with regulatory oversight.